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Results will be sent to you by email:  
Input FASTA file (example here):  
Choose an option:
FoldAmyloid (article) (try it by yourself)
AGGRESCAN (article) (try it by yourself)
FiSH (article) (try it by yourself)
Check for the presence of sequence fragments from the database

Other analysis methods not implemented (yet):
  • 3D Profile Method (see article) (try it)
    • Structure-based algorithm using crystal structure of the fibril-forming peptide NNQQNY from the sup35 prion protein of Saccharomyces cerevisiae in order to compute fibrillation propensities.
  • AGGRESCAN3D (see article) (try it)
    • A webserver for prediction of aggregation propensity in protein structures and rational design of protein solubility. Based on an experimentally derived intrinsic aggregation propensity scale for natural amino acids used in AGGRESCAN method.
  • AmyloidMutants (see article) (try it)
    • A webserver which computes a predicted sequence/structure landscape of an amyloid fibril and samples sequences and their corresponding full structure.
  • AMYLPRED (see article) (try it)
    • Consensus method which uses different algorithms developed to predict features related to the formation of amyloid fibrils.
  • AMYLPRED2 (see article) (try it)
    • Improved version of AMYLPRED.
  • MetAmyl (see article) (try it)
    • Amyloidogenesis meta-predictor which combines the results of such predictors like PAFIG, SALSA, Waltz and FoldAmyloid.
  • NetCSSP (see article) (try it)
    • Neural networks for calculating Contact-dependent Secondary Structure Propensity predicting non-native secondary structures and amyloid fibril formation.
  • Pafig (see article) (try it)
    • Method based on support vector machines which exploits 41 physicochemical properties to identify fibrillar aggregating regions in protein sequence.
  • PASTA (see article) (try it)
    • A webserver predicting sequence fragments which are more likely to stabilize the cross-beta core of fibrillar aggregates.
  • SALSA (see article)
    • Algorithm which calculates an average β-strand propensity score of a peptide window using Chou and Fasman β-strand preference numbers (Chou and Fasman 1974).
  • TANGO (see article) (try it)
    • A statistical mechanics algorithm based on physico-chemical principles of secondary structure formation.
  • WALTZ (see article) (try it)
    • Web-based tool that uses a position-specific scoring matrix to determine amyloid-forming sequences. Method built on the data of experimentally derived amyloid hexapeptides.
  • Zyggregator (see article) (try it)
    • A sequence-based method of predicting aggregation propensities of proteins.
© 2014 Powered by Paweł P. Woźniak
administrative contact: pawel.p.wozniak@pwr.edu.pl
If you used this service please cite:
Wozniak PP, Kotulska M, AmyLoad – website dedicated to amyloidogenic protein fragments,
Bioinformatics 2015 Jun 17. doi: 10.1093/bioinformatics/btv375